{"id":8655,"date":"2026-04-08T09:15:37","date_gmt":"2026-04-08T09:15:37","guid":{"rendered":"https:\/\/healaxispharma.com\/?post_type=product&#038;p=8655"},"modified":"2026-04-23T10:53:16","modified_gmt":"2026-04-23T10:53:16","slug":"epirubicin-hydrochloride-injection","status":"publish","type":"product","link":"https:\/\/healaxispharma.com\/?product=epirubicin-hydrochloride-injection","title":{"rendered":"Epirubicin Hydrochloride Injection"},"content":{"rendered":"<h2 class=\"wp-block-heading\"><strong>What is Epirubicin Hydrochloride Injection?<\/strong><\/h2>\n<p>Epirubicin Hydrochloride Injection is a strong chemotherapy drug that is mostly used to treat different types of cancer, especially breast cancer, which is still in its early stages.<\/p>\n<p>It is a different form of anthracycline that has a structure similar to doxorubicin but a changed side chain that makes it less harmful to the heart.<\/p>\n<p>The way epirubicin works is by stopping cancer cells from growing, which kills them in the end.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Overview<\/strong><\/h2>\n<div id=\"ilbIconList-d63d30e0-0\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-angles-right\"><\/i>\n<p class=\"text\"><strong>Drug Class:<\/strong>\u00a0Anthracycline antineoplastic (antibiotic)<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-angles-right\"><\/i>\n<p class=\"text\"><strong>Administration Method:<\/strong>\u00a0Intravenous (IV) exclusively<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-angles-right\"><\/i>\n<p class=\"text\"><strong>Chemical Formula:<\/strong>\u00a0C27H29NO11\u00b7HCl<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-angles-right\"><\/i>\n<p class=\"text\"><strong>Molecular Weight:<\/strong>\u00a0579.98 g\/mol<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<h2 class=\"wp-block-heading\"><strong>Description<\/strong><\/h2>\n<p>Epirubicin Hydrochloride is a semi-synthetic analog of doxorubicin, distinguished by a modification at the 4\u2032 position of the sugar molecule.<\/p>\n<p>The medication is formulated as a red-orange solution for intravenous administration.<\/p>\n<p>Each milliliter comprises Epirubicin Hydrochloride (equal to epirubicin base), typically 2 mg\/mL<\/p>\n<p><strong>Excipients:<\/strong>\u00a0Sodium chloride, hydrochloric acid (for pH adjustment), and Water for Injection<\/p>\n<p>It is a cytotoxic anthracycline antibiotic that targets DNA to provide its anti-tumor actions.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Uses \/ Indications<\/strong><\/h2>\n<p>Metastatic breast cancer<\/p>\n<p>Gastric cancer<\/p>\n<p>Ovarian carcinoma<\/p>\n<p>Non-small cell lung cancer (NSCLC)<\/p>\n<p>Hepatocellular carcinoma<\/p>\n<p>Bladder cancer<\/p>\n<h2 class=\"wp-block-heading\"><strong>Benefits<\/strong><\/h2>\n<p>The overall survival rate and the percentage of breast cancer patients who are disease-free are both improved.<\/p>\n<p>Because it is less cardiotoxic than doxorubicin, increased cumulative dosages can be administered to certain patients.<\/p>\n<p>Used in the treatment of a wide spectrum of solid and hematological cancers.<\/p>\n<p>Strong efficacy can be achieved by the use of well-established combination regimens, such as CEF, EC, and ECF.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Side Effects<\/strong><\/h2>\n<div id=\"ilbIconList-bc848e9d-e\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-arrow-right\"><\/i>\n<p class=\"text\"><strong>Common Side Effects:<\/strong><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"ilbIconList-d3115090-a\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Nausea and puking<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Mucositis and stomatitis<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Diarrhea or constipation<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Alopecia (hair loss)<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Fatigue and malaise<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Skin hyperpigmentation<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Nail discoloration<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"ilbIconList-d3a117ce-9\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-arrow-right\"><\/i>\n<p class=\"text\"><strong>Serious Side Effects:<\/strong><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"ilbIconList-8647adc2-f\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Cardiotoxicity<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Myelosuppression<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Secondary Leukemia (AML or MDS)<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Hepatotoxicity<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Local Tissue Necrosis<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<h2 class=\"wp-block-heading\"><strong>How Does It Work?<\/strong><\/h2>\n<p>Cancer cells\u2019 DNA is messed up by epirubicin, which is how it works.<\/p>\n<p>By intercalating itself into DNA strands, it stops enzymes like topoisomerase II from doing their job of copying and fixing DNA.<\/p>\n<p>This breaks down the DNA, which stops the cancer cells from spreading and dividing.<\/p>\n<p>Also, epirubicin makes free radicals that hurt parts of cells and eventually cause apoptosis, which is the death of rapidly developing tumor cells.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Directions for Use<\/strong><\/h2>\n<p>Only intravenously (IV) is administered; no intramuscular or intrathecal administration occurs.<\/p>\n<p>Dosage is determined by body surface area (mg\/m\u00b2) and kind of malignancy.<\/p>\n<p>Typically administered slowly over 3-20 minutes by central or peripheral vein.<\/p>\n<p>Use a central venous catheter to reduce the risk of extravasation.<\/p>\n<p>Refrain from mixing with other medicines in the same infusion line.<\/p>\n<h2 class=\"wp-block-heading\"><strong>When Not to Use<\/strong><\/h2>\n<p>Epirubicin or other anthracyclines are known to cause allergies or high levels of sensitivity.<\/p>\n<p>People whose livers are severely damaged or whose liver function tests come back odd.<\/p>\n<p>A history of chronic heart failure or a low LVEF will be taken into account.<\/p>\n<p>Before, the total amount of anthracycline taken was more than what is suggested.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Drug Interactions<\/strong><\/h2>\n<p>The co-administration of trastuzumab elevates the risk of heart failure.<\/p>\n<p>Administering paclitaxel or docetaxel prior to epirubicin may amplify its toxicity.<\/p>\n<p>CYP3A4 inhibitors, such as ketoconazole, can elevate epirubicin plasma concentrations.<\/p>\n<p>Live vaccinations can induce serious infections as a result of immune suppression.<\/p>\n<p>Additional anthracyclines or alkylating drugs augment cumulative toxicity.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Safety Advice<\/strong><\/h2>\n<p><a href=\"https:\/\/chemm.hhs.gov\/pregnancycategories.htm#:~:text=despite%20potential%20risks.-,Category%20D,-There%20is%20positive\" target=\"_blank\" rel=\"noopener noreferrer nofollow\" data-type=\"link\" data-id=\"https:\/\/chemm.hhs.gov\/pregnancycategories.htm#:~:text=despite%20potential%20risks.-,Category%20D,-There%20is%20positive\">Pregnancy Category D<\/a>\u00a0\u2013 Conclusive evidence of danger to human fetuses; use is not advised unless critically required.<\/p>\n<p>Employ reliable contraception during therapy and for six months thereafter.<\/p>\n<p>Refrain from breastfeeding while undergoing therapy.<\/p>\n<p>People with hepatic or renal impairment should be administered modified dosages.<\/p>\n<p>Utilize central venous access to mitigate extravasation hazards.<\/p>\n<h2 class=\"wp-block-heading\"><strong>General Instructions<\/strong><\/h2>\n<p>Report right away any chest pain, shortness of breath, fever, or other signs of an infection.<\/p>\n<p>Stay away from busy places and sick people.<\/p>\n<p>Rinse your mouth out often to lower your risk of mucositis.<\/p>\n<p>Do not miss any doses; stick to the treatment plan.<\/p>\n<p>It\u2019s normal and safe to have red pee after getting an injection.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Special Dietary \/ Lifestyle Advice<\/strong><\/h2>\n<p>Patients undergoing Epirubicin Hydrochloride Injection should eat a well-balanced diet rich in fruits, vegetables, and lean proteins to support immunological function and recuperation.<\/p>\n<p>Staying hydrated is essential for flushing the medication and its metabolites from the body.<\/p>\n<p>Avoid alcohol and tobacco, as these can put a burden on your liver and heart.<\/p>\n<p>Light physical activity, such as walking, can assist in reducing fatigue, but strenuous exercise should be avoided throughout therapy.<\/p>\n<p>Take care of your teeth to prevent mouth sores.<\/p>\n<p>Also, avoid sun exposure since the medicine can make your skin sensitive.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Comparison with Other Treatments<\/strong><\/h2>\n<p>In some patients, epirubicin can be given higher cumulative doses than doxorubicin since it has a lower cardiotoxicity risk.<\/p>\n<p>Both treat breast and other solid tumors; however, epirubicin is safer for borderline cardiac patients.<\/p>\n<p>Epirubicin is less expensive and more commonly used in chemotherapy than liposomal doxorubicin.<\/p>\n<p>However, it leads to more hair loss and mucositis.<\/p>\n<p>It is sometimes recommended over mitoxantrone, which has less cardiac risk but weaker anti-tumor effectiveness.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Precautions &amp; Warnings<\/strong><\/h2>\n<p>Patients with pre-existing cardiac disease should exercise caution.<\/p>\n<p>Keep an eye on the total dosage (no more than 900 mg\/m2) to prevent heart damage.<\/p>\n<p>Think about baseline and recurring echocardiograms.<\/p>\n<p>As a vesicant, epirubicin should be handled carefully to avoid extravasation.<\/p>\n<p>May result in infertility, either temporarily or permanently.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Can It Be Used With Other Medications?<\/strong><\/h2>\n<div id=\"ilbIconList-f294535a-c\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-brands fa-artstation\"><\/i>\n<p class=\"text\"><strong>Often used with<\/strong><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p><a href=\"https:\/\/www.actizapharma.com\/product\/cyclophosphamide-tablets\/\" data-type=\"link\" data-id=\"https:\/\/www.actizapharma.com\/product\/cyclophosphamide-tablets\/\">Cyclophosphamide\u00a0<\/a>+ 5-FU (CEF regimen) \u2013 standard in breast cancer<\/p>\n<p>Docetaxel (EC-T regimen) \u2013 highly effective in early breast cancer<\/p>\n<p><a href=\"https:\/\/www.actizapharma.com\/product\/cisplatin-injection\/\" data-type=\"link\" data-id=\"https:\/\/www.actizapharma.com\/product\/cisplatin-injection\/\">Cisplatin\u00a0<\/a>+ 5-FU (ECF regimen) \u2013 used for gastric cancers<\/p>\n<div id=\"ilbIconList-48f018ab-e\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-brands fa-artstation\"><\/i>\n<p class=\"text\"><strong>Avoid or monitor closely with<\/strong><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p>Trastuzumab or lapatinib \u2013 monitor heart function closely<\/p>\n<p>Other anthracyclines or alkylating agents \u2013 cumulative toxicity<\/p>\n<p>Hepatotoxic drugs (e.g., methotrexate) \u2013 adjust the dose<\/p>\n<h2 class=\"wp-block-heading\"><strong>Storage<\/strong><\/h2>\n<p>Refrigerate and keep at 2 to 8 degrees Celsius.<\/p>\n<p>Be careful not to freeze<\/p>\n<p>Shield from intense heat and light.<\/p>\n<p>Reconstitute and use within 24 hours if kept refrigerated.<\/p>\n<p>Because it is cytotoxic, dispose of any leftovers in a secure manner.<\/p>\n","protected":false},"excerpt":{"rendered":"<table class=\"shop_attributes table mt-2 align-middle\">\n<tbody>\n<tr>\n<th class=\"table-light\">Product\/Composition:-<\/th>\n<td class=\"p-2\"><em>Epirubicin Hydrochloride Injection<\/em><\/td>\n<\/tr>\n<tr>\n<th class=\"table-light\">Strength:-<\/th>\n<td class=\"p-2\"><em>10mg, 50mg, 100mg<\/em><\/td>\n<\/tr>\n<tr>\n<th class=\"table-light\">Form:-<\/th>\n<td class=\"p-2\"><em>Injection<\/em><\/td>\n<\/tr>\n<tr>\n<th class=\"table-light\">Production Capacity:-<\/th>\n<td class=\"p-2\"><em>1 Million Injection\/Month<\/em><\/td>\n<\/tr>\n<tr>\n<th class=\"table-light\">Therapeutic use:-<\/th>\n<td class=\"p-2\"><em>Anti Cancer<\/em><\/td>\n<\/tr>\n<tr>\n<th class=\"table-light\">Package Insert\/Leaflet:-<\/th>\n<td class=\"p-2\"><em>Available upon request<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"featured_media":8657,"comment_status":"open","ping_status":"closed","template":"","meta":{"inline_featured_image":false},"product_brand":[],"product_cat":[15,91,113],"product_tag":[157],"class_list":{"0":"post-8655","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-all-medicine","7":"product_cat-anti-cancer-drugs","8":"product_cat-injection-anti-cancer-drugs","9":"product_tag-injection","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/healaxispharma.com\/index.php?rest_route=\/wp\/v2\/product\/8655","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healaxispharma.com\/index.php?rest_route=\/wp\/v2\/product"}],"about":[{"href":"https:\/\/healaxispharma.com\/index.php?rest_route=\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/healaxispharma.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8655"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/healaxispharma.com\/index.php?rest_route=\/wp\/v2\/media\/8657"}],"wp:attachment":[{"href":"https:\/\/healaxispharma.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8655"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/healaxispharma.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_brand&post=8655"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/healaxispharma.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_cat&post=8655"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/healaxispharma.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_tag&post=8655"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}