{"id":8702,"date":"2026-04-08T09:58:19","date_gmt":"2026-04-08T09:58:19","guid":{"rendered":"https:\/\/healaxispharma.com\/?post_type=product&#038;p=8702"},"modified":"2026-04-23T10:53:14","modified_gmt":"2026-04-23T10:53:14","slug":"irinotecan-hydrochloride-injection","status":"publish","type":"product","link":"https:\/\/healaxispharma.com\/?product=irinotecan-hydrochloride-injection","title":{"rendered":"Irinotecan Hydrochloride Injection"},"content":{"rendered":"<h2 class=\"wp-block-heading\"><strong>What is Irinotecan Hydrochloride?<\/strong><\/h2>\n<p>Chemotherapy drugs like irinotecan hydrochloride are used to treat different types of cancer, especially colon cancer that has spread to other parts of the body.<\/p>\n<p>This medicine is a topoisomerase I inhibitor, and it works against the machinery that cancer cells use to copy DNA.<\/p>\n<p>The drug Irinotecan was created from the natural compound camptothecin.<\/p>\n<p>It is given through an IV and is normally mixed with other chemotherapeutics like 5-fluorouracil and Leucovorin.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Overview<\/strong><\/h2>\n<div id=\"ilbIconList-fd177fc9-7\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-angles-right\"><\/i>\n<p class=\"text\"><strong>Classification:<\/strong>\u00a0Antineoplastic agent; Inhibitor of Topoisomerase I<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-angles-right\"><\/i>\n<p class=\"text\"><strong>Formulation:<\/strong>\u00a0Aseptic intravenous injection<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-angles-right\"><\/i>\n<p class=\"text\"><strong>Prescription Status:<\/strong>\u00a0Prescription required (Rx-only)<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-angles-right\"><\/i>\n<p class=\"text\"><strong>Route of Administration:<\/strong>\u00a0Intravenous (IV)<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-angles-right\"><\/i>\n<p class=\"text\"><strong>Metabolite:<\/strong>\u00a0Transformed in the liver into SN-38, the primary cytotoxic agent.<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<h2 class=\"wp-block-heading\"><strong>Description<\/strong><\/h2>\n<p>Irinotecan Hydrochloride is a chemical that is partly made in a lab that is similar to camptothecin, which is a poisonous alkaloid that comes from the Chinese tree Camptotheca acuminata.<\/p>\n<p>It comes in vials that are stable for intravenous application and are a clear to pale yellow solution.<\/p>\n<div id=\"ilbIconList-cac0cde4-e\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-arrows-turn-right\"><\/i>\n<p class=\"text\"><strong>Molecule Formula:<\/strong>\u00a0C33H38N4O6\u00b7HCl\u00b73H2O<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-arrows-turn-right\"><\/i>\n<p class=\"text\"><strong>Molecular weight:<\/strong>\u00a0677.19 g\/mol.<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<h2 class=\"wp-block-heading\"><strong>Uses of Irinotecan Hydrochloride<\/strong><\/h2>\n<h3 class=\"wp-block-heading\"><strong>Primary Uses<\/strong><\/h3>\n<p>Colorectal cancer that has spread<\/p>\n<p>Adenocarcinoma of the pancreas<\/p>\n<p>Small cell lung cancer, cervical cancer, and stomach cancer<\/p>\n<h3 class=\"wp-block-heading\"><strong>Indications<\/strong><\/h3>\n<p>5-fluorouracil and leucovorin are used as a first-line treatment for colon cancer that has spread.<\/p>\n<p>Second-line treatment for people who have gotten worse on fluorouracil alone.<\/p>\n<p>If you have recurrent or advanced pancreatic cancer, you can use the liposomal version with other drugs.<\/p>\n<p>It is also being tested for use in other solid cancers, such as ovarian and non-small cell lung cancer.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Benefits<\/strong><\/h2>\n<p>Enhanced overall survival and progression-free survival rates in people with metastatic colorectal cancer.<\/p>\n<p>Reliable either alone or as part of a mixed regimen such as FOLFIRI.<\/p>\n<p>Liposomal Irinotecan provides targeted delivery and extended medication exposure for pancreatic cancer patients.<\/p>\n<p>In comparison to fluorouracil alone, it improves tumor shrinkage and response rate.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Side Effects<\/strong><\/h2>\n<div id=\"ilbIconList-27f2df7b-0\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-arrow-right\"><\/i>\n<p class=\"text\"><strong>Very Common<\/strong><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"ilbIconList-d54152ba-f\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Diarrhea<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Nausea<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Vomiting<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Hair loss (Alopecia)<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Weakness (Asthenia)<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Decreased appetite<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"ilbIconList-805990cb-e\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-arrow-right\"><\/i>\n<p class=\"text\"><strong>Serious or Rare<\/strong><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"ilbIconList-078dc146-6\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Severe diarrhea<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Febrile neutropenia<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Severe allergic reactions<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Interstitial lung disease<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Thrombocytopenia<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Intestinal perforation<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<h2 class=\"wp-block-heading\"><strong>How Does Irinotecan Work?<\/strong><\/h2>\n<p>Irinotecan is a prodrug that is converted in the liver to SN-38, a strong inhibitor of topoisomerase I.<\/p>\n<p>Topoisomerase I is the enzyme that relaxes supercoiled DNA during replication and transcription.<\/p>\n<p>SN-38 binds to the topoisomerase I-DNA complex, making it stable and stopping strand displacement, which results in DNA strand breaks.<\/p>\n<p>This method causes cell cycle arrest and death, particularly in rapidly dividing tumor cells.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Dosage Guidelines<\/strong><\/h2>\n<p>Monotherapy (second-line colorectal cancer): 125 mg\/m\u00b2 IV over 1.5 hours weekly for 4 weeks, forwarded by 14-day rest<\/p>\n<p>Combination (FOLFIRI regimen): 180 mg\/m\u00b2 IV every 14 days with 5-FU and leucovorin<\/p>\n<p>Liposomal formulation (pancreatic cancer): 70 mg\/m\u00b2 every 2 weeks (equivalent to 50 mg\/m\u00b2 Irinotecan free base)<\/p>\n<h2 class=\"wp-block-heading\"><strong>Directions for Use<\/strong><\/h2>\n<p>Only given in a clinical setting by trained medical experts.<\/p>\n<p>Given through an IV over 90 minutes.<\/p>\n<p>Before treatment, you may start to stay hydrated and avoid having diarrhea.<\/p>\n<p>During the infusion, keep an eye out for hypersensitivity and take care of any signs right away.<\/p>\n<h2 class=\"wp-block-heading\"><strong>When Not to Use<\/strong><\/h2>\n<p>If you might be allergic to Irinotecan or any of its parts<\/p>\n<p>Strong suppression of the bone marrow<\/p>\n<p>During pregnancy and while breastfeeding (Category D)<\/p>\n<p>People who have inflammatory bowel disease or prolonged diarrhea<\/p>\n<p>Severe liver damage (bilirubin &gt;2 mg\/dL)<\/p>\n<h2 class=\"wp-block-heading\"><strong>Drug Interactions<\/strong><\/h2>\n<div id=\"ilbIconList-7f3060ba-7\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-regular fa-hand-point-right\"><\/i>\n<p class=\"text\"><a href=\"https:\/\/www.actizapharma.com\/product\/phenytoin-sodium-tablets\/\" data-type=\"link\" data-id=\"https:\/\/www.actizapharma.com\/product\/phenytoin-sodium-tablets\/\">Phenytoin<\/a><\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-regular fa-hand-point-right\"><\/i>\n<p class=\"text\">Carbamazepine<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-regular fa-hand-point-right\"><\/i>\n<p class=\"text\">Rifampin<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-regular fa-hand-point-right\"><\/i>\n<p class=\"text\"><a href=\"https:\/\/www.actizapharma.com\/product\/ketoconazole-tablets\/\" data-type=\"link\" data-id=\"https:\/\/www.actizapharma.com\/product\/ketoconazole-tablets\/\">Ketoconazole<\/a><\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-regular fa-hand-point-right\"><\/i>\n<p class=\"text\">Atazanavir<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-regular fa-hand-point-right\"><\/i>\n<p class=\"text\">Indinavir<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-regular fa-hand-point-right\"><\/i>\n<p class=\"text\">Nelfinavir<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-regular fa-hand-point-right\"><\/i>\n<p class=\"text\">Ritonavir<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<h2 class=\"wp-block-heading\"><strong>Safety Advice<\/strong><\/h2>\n<p>Drinking alcohol might amplify symptoms like dizziness or diarrhea, so it\u2019s best to stay away from it.<\/p>\n<p>Do not use unless absolutely required during pregnancy; it is not safe and may harm the unborn child.<\/p>\n<p>If you are nursing a baby, don\u2019t feed your child for at least 1 week after your last dosage and during your therapy.<\/p>\n<p>The medicine can cause drowsiness, lightheadedness, or vision problems. So, don\u2019t drive while using it.<\/p>\n<h2 class=\"wp-block-heading\"><strong>General Instructions<\/strong><\/h2>\n<p>The only person who should give Irinotecan Hydrochloride Injection is a trained medical professional who knows how to use\u00a0<a href=\"https:\/\/www.mayoclinic.org\/tests-procedures\/chemotherapy\/about\/pac-20385033#:~:text=Overview,most%20cells%20in%20the%20body.\" target=\"_blank\" rel=\"noopener noreferrer nofollow\" data-type=\"link\" data-id=\"https:\/\/www.mayoclinic.org\/tests-procedures\/chemotherapy\/about\/pac-20385033#:~:text=Overview,most%20cells%20in%20the%20body.\">chemotherapeutic\u00a0<\/a>agents for cancer.<\/p>\n<p>It is given through an IV, generally in a hospital or clinic. Before and after treatment, patients should drink a lot of water and tell any symptoms right away, such as severe diarrhea, fever, or signs of an infection.<\/p>\n<p>Blood counts and liver activity need to be observed frequently with blood tests.<\/p>\n<p>It is very important to stick to the dosing plan and not miss any doses unless your doctor tells you to.<\/p>\n<p>Always discuss with a doctor about all of the drugs and vitamins you are taking.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Special Diet &amp; Lifestyle Recommendations<\/strong><\/h2>\n<p>Keep up good fluid intake to avoid dehydration.<\/p>\n<p>Steer clear of foods that could aggravate diarrhea (such as highly fatty or spicy meals).<\/p>\n<p>Eat easy on the stomach, modest, regular meals.<\/p>\n<p>Avoid grapefruit juice and booze.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Comparison with Other Cancer Therapies<\/strong><\/h2>\n<p>Irinotecan Hydrochloride is a topoisomerase I inhibitor that is mostly used to treat colon cancer that has spread, usually with other drugs like Folfiri.<\/p>\n<p>Irinotecan is different from other types of chemotherapy because it targets DNA replication enzymes specifically.<\/p>\n<p>This makes it very effective against some kinds of tumors.<\/p>\n<p>Irinotecan has more systemic side effects, such as diarrhea and neutropenia, than targeted treatments (like cetuximab) or immunotherapies (like nivolumab).<\/p>\n<p>But the fact that it works well with other drugs is very helpful in cases of advanced cancer, especially when other drugs stop working.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Precautions &amp; Warnings<\/strong><\/h2>\n<p>It is possible that pregnancy category D will cause harm to the fetus. It is not suggested unless it is manifestly required.<\/p>\n<p>Due to the possibility of causing harm to the baby, nursing is not recommended.<\/p>\n<p>Safety and efficacy in children\u2019s utilization have not been thoroughly investigated.<\/p>\n<p>Use in elderly patients is associated with an increased incidence of adverse effects, particularly neutropenia.<\/p>\n<p>If it is clinically indicated, UGT1A1 genotyping should be performed in order to evaluate the risk of toxicity.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Can It Be Taken with Other Medicines?<\/strong><\/h2>\n<p>Irinotecan Hydrochloride may interact with other drugs, so use cautious.<\/p>\n<p>It is often given alongside 5-fluorouracil and Leucovorin to treat cancer.<\/p>\n<p>Enzyme inducers (Phenytoin, rifampin), CYP3A4 inhibitors (Ketoconazole, Ritonavir), and herbal supplements like St.<\/p>\n<p>John\u2019s Wort can reduce its efficacy or raise its toxicity.<\/p>\n<p>Before starting Irinotecan, tell your doctor about all prescription, over-the-counter, and supplement drugs.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Storage<\/strong><\/h2>\n<p>The recommended storage temperature for vials is 20-25\u00b0C, or 68-77\u00b0F.<\/p>\n<p>Avoid freezing and keep away from direct sunrays.<\/p>\n<p>Use or store diluted solutions as the manufacturer says.<\/p>\n<p>Usually, you should do this within 6 hours at room temperature or within 24 hours in the fridge.<\/p>\n","protected":false},"excerpt":{"rendered":"<table class=\"shop_attributes table mt-2 align-middle\">\n<tbody>\n<tr>\n<th class=\"table-light\">Product\/Composition:-<\/th>\n<td class=\"p-2\"><em>Irinotecan Hydrochloride Injection<\/em><\/td>\n<\/tr>\n<tr>\n<th class=\"table-light\">Strength:-<\/th>\n<td class=\"p-2\"><em>20mg\/ml<\/em><\/td>\n<\/tr>\n<tr>\n<th class=\"table-light\">Form:-<\/th>\n<td class=\"p-2\"><em>Injection<\/em><\/td>\n<\/tr>\n<tr>\n<th class=\"table-light\">Production Capacity:-<\/th>\n<td class=\"p-2\"><em>1 Million Injection\/Month<\/em><\/td>\n<\/tr>\n<tr>\n<th class=\"table-light\">Therapeutic use:-<\/th>\n<td class=\"p-2\"><em>Anti Cancer<\/em><\/td>\n<\/tr>\n<tr>\n<th class=\"table-light\">Package Insert\/Leaflet:-<\/th>\n<td class=\"p-2\"><em>Available upon request<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"featured_media":8703,"comment_status":"open","ping_status":"closed","template":"","meta":{"inline_featured_image":false},"product_brand":[],"product_cat":[15,91,113],"product_tag":[157],"class_list":{"0":"post-8702","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-all-medicine","7":"product_cat-anti-cancer-drugs","8":"product_cat-injection-anti-cancer-drugs","9":"product_tag-injection","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/healaxispharma.com\/index.php?rest_route=\/wp\/v2\/product\/8702","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healaxispharma.com\/index.php?rest_route=\/wp\/v2\/product"}],"about":[{"href":"https:\/\/healaxispharma.com\/index.php?rest_route=\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/healaxispharma.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8702"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/healaxispharma.com\/index.php?rest_route=\/wp\/v2\/media\/8703"}],"wp:attachment":[{"href":"https:\/\/healaxispharma.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8702"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/healaxispharma.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_brand&post=8702"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/healaxispharma.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_cat&post=8702"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/healaxispharma.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_tag&post=8702"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}