{"id":8710,"date":"2026-04-09T03:57:09","date_gmt":"2026-04-09T03:57:09","guid":{"rendered":"https:\/\/healaxispharma.com\/?post_type=product&#038;p=8710"},"modified":"2026-04-23T10:53:14","modified_gmt":"2026-04-23T10:53:14","slug":"leucovorin-injection","status":"publish","type":"product","link":"https:\/\/healaxispharma.com\/?product=leucovorin-injection","title":{"rendered":"Leucovorin Injection"},"content":{"rendered":"<h2 class=\"wp-block-heading\"><strong>What is Leucovorin?<\/strong><\/h2>\n<p>Folic acid (vitamin B9) is turned into leucovorin, which is also called folinic acid.<\/p>\n<p>Leucovorin does not require to be activated by dihydrofolate reductase.<\/p>\n<p>This means it can get around some barriers in the folate metabolic route.<\/p>\n<p>It\u2019s mostly used as a rescue agent that can help mitigate the adverse effects of high-dose methotrexate.<\/p>\n<p>Fluorouracil (5-FU) can be used more effectively to treat cancer with this chemosensitizer.<\/p>\n<p>A supplement that adds folate to the body when it is lacking or too much antifolate is being used.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Overview<\/strong><\/h2>\n<div id=\"ilbIconList-ecebd5ad-0\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-angles-right\"><\/i>\n<p class=\"text\"><strong>Generic Name:<\/strong>\u00a0Calcium leucovorin<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-angles-right\"><\/i>\n<p class=\"text\"><strong>Class of Drug:<\/strong>\u00a0Folate analog\/derivative of vitamin B-complex<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-angles-right\"><\/i>\n<p class=\"text\"><strong>Formulations:<\/strong>\u00a0IV or IM injectable solution<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<h2 class=\"wp-block-heading\"><strong>Description<\/strong><\/h2>\n<p>Leucovorin is an important supporting drug in chemotherapy treatments.<\/p>\n<p>By adding folate to cells that have lost it, it protects them from the harmful effects of folate antagonists, such as methotrexate.<\/p>\n<p>It is also used to enhance the cancer-fighting effects of drugs like 5-FU, which prevent cancer cells from replicating their DNA when they divide rapidly.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Uses \/ Indications<\/strong><\/h2>\n<p>Rescue therapy following high-dose methotrexate to mitigate damage in healthy cells.<\/p>\n<p>Adjuvant therapy in colorectal cancer with 5-fluorouracil (5-FU) to augment anticancer effectiveness.<\/p>\n<p>Managing toxicity from folate antagonists includes handling overdoses of methotrexate, Trimethoprim, or pyrimethamine.<\/p>\n<p>Management of megaloblastic anaemia resulting from folate insufficiency in particular clinical contexts.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Benefits<\/strong><\/h2>\n<p>During the chemotherapeutic treatment with methotrexate, it safeguards healthy cells.<\/p>\n<p>Used in conjunction with 5-FU, it improves the response to chemotherapy.<\/p>\n<p>Reverses the harmful effects of antifolate promptly and efficiently.<\/p>\n<p>The medication is well-tolerable and poses a lower chance of serious adverse reactions.<\/p>\n<p>Crucial in the field of pediatric oncology, particularly for patients suffering from leukemia.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Side Effects<\/strong><\/h2>\n<div id=\"ilbIconList-357acc3a-f\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-arrow-right\"><\/i>\n<p class=\"text\"><strong>Common<\/strong><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"ilbIconList-f6e80dde-8\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Diarrhea<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Nausea<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Vomiting<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Fatigue<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Stomatitis (mouth sores)<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Injection site pain or swelling<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"ilbIconList-861edb39-b\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-arrow-right\"><\/i>\n<p class=\"text\"><strong>Rare but Serious:<\/strong><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"ilbIconList-681d573d-7\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Hypersensitivity reactions<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Seizures<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Difficulty breathing, wheezing, chest tightness<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Severe skin reactions<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<h2 class=\"wp-block-heading\"><strong>How Does It Work?<\/strong><\/h2>\n<p>Leucovorin is the usual folate rescue agent that is often used with methotrexate and 5-fluorouracil (5-FU).<\/p>\n<p>It can get around dihydrofolate reductase (DHFR) and restore folate stores that have been lost.<\/p>\n<p>Levoleucovorin is the active L-isomer of leucovorin. It is more bioavailable and potent.<\/p>\n<p>This means it can be used in smaller doses but still offers the same therapeutic benefits.<\/p>\n<p>Folic acid looks a lot like methotrexate. However, it can\u2019t help methotrexate because it relies on DHFR activity.<\/p>\n<p>Methotrexate blocks this activity. Calcium folinate is just another name for leucovorin, and it works the same way.<\/p>\n<p>If leucovorin rescue isn\u2019t enough for severe methotrexate toxicity, glucarpidase can help.<\/p>\n<p>It quickly breaks down methotrexate, offering another way to detoxify.<\/p>\n<h2 class=\"wp-block-heading\"><strong>How to Use \/ Dosage Guidelines<\/strong><\/h2>\n<p>Give leucovorin 24 hours following high-dose methotrexate, usually 10-15 mg\/m\u00b2 every 6 hours.<\/p>\n<p>For colorectal cancer, administer 20-500 mg\/m\u00b2 IV before or with 5-FU.<\/p>\n<p>To treat antifolate toxicity, provide 3-15 mg\/day IV\/IM until hematologic recovery.<\/p>\n<p>Under medical supervision, the medication is administered either intravenous (IV) or intramuscular (IM).<\/p>\n<p>The dose and length of treatment are determined by methotrexate levels, renal function, and patient response.<\/p>\n<h2 class=\"wp-block-heading\"><strong>When Not to Use<\/strong><\/h2>\n<p>A hypersensitivity that is known to exist to leucovorin or calcium folinate<\/p>\n<p>Both pernicious anaemia and B12-deficiency anaemia have the potential to conceal symptoms.<\/p>\n<p>Methotrexate administered intravenously at the same time poses a risk of lethal neurotoxicity.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Drug Interactions<\/strong><\/h2>\n<div id=\"ilbIconList-cb9c5dc1-7\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-regular fa-hand-point-right\"><\/i>\n<p class=\"text\"><strong><a href=\"https:\/\/www.actizapharma.com\/product\/methotrexate-tablets\/\" data-type=\"link\" data-id=\"https:\/\/www.actizapharma.com\/product\/methotrexate-tablets\/\">Methotrexate<\/a>:<\/strong>\u00a0Reduces toxicity (intended)<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-regular fa-hand-point-right\"><\/i>\n<p class=\"text\"><strong>5-Fluorouracil (5-FU):<\/strong>\u00a0Increases efficacy (intended)<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-regular fa-hand-point-right\"><\/i>\n<p class=\"text\"><strong>Phenytoin, Phenobarbital, Primidone:<\/strong>\u00a0Decreased serum levels \u2192 possible seizure risk<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-regular fa-hand-point-right\"><\/i>\n<p class=\"text\"><strong>Sulfonamides, Trimethoprim:<\/strong>\u00a0May reduce antifolate efficacy<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<h2 class=\"wp-block-heading\"><strong>Safety Advice<\/strong><\/h2>\n<div id=\"ilbIconList-1630b0e6-d\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-arrow-right-to-bracket\"><\/i>\n<p class=\"text\"><strong>Renal surveillance:<\/strong>\u00a0Essential during methotrexate treatment<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-arrow-right-to-bracket\"><\/i>\n<p class=\"text\"><strong>History of seizures:<\/strong>\u00a0Exercise caution<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-arrow-right-to-bracket\"><\/i>\n<p class=\"text\"><strong>Standard blood examinations:<\/strong>\u00a0Complete Blood Count (CBC), renal function testing, hepatic enzyme levels<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-arrow-right-to-bracket\"><\/i>\n<p class=\"text\"><strong>Pregnancy and breastfeeding:<\/strong>\u00a0Utilize only when absolutely necessary; seek medical advice.<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<h2 class=\"wp-block-heading\"><strong>General Instructions<\/strong><\/h2>\n<p>A medical professional always carries out administration.<\/p>\n<p>Look out for any adverse responses, such as a rash, convulsions, or difficulty breathing.<\/p>\n<p>Ensure that you consume a sufficient amount of water throughout your methotrexate cycles.<\/p>\n<p>Make sure to report any unusual signs of infection, such as exhaustion or bruises.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Special Dietary &amp; Lifestyle Tips<\/strong><\/h2>\n<p>Maintaining proper hydration is especially important during methotrexate treatment.<\/p>\n<p>Consume no alcohol because it may affect liver function.<\/p>\n<p><a href=\"https:\/\/www.healthline.com\/nutrition\/foods-high-in-folate-folic-acid\" target=\"_blank\" rel=\"noopener noreferrer nofollow\" data-type=\"link\" data-id=\"https:\/\/www.healthline.com\/nutrition\/foods-high-in-folate-folic-acid\">Dietary folate-rich foods<\/a>\u00a0include citrus fruits, lentils, and leafy greens.<\/p>\n<p>Folic acid should not be used for self-injecting without an expert lookout.<\/p>\n<p>During chemotherapy, remain consistent with your schedule.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Comparison with Similar Agents<\/strong><\/h2>\n<div id=\"ilbIconList-641c64f7-1\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-arrows-turn-right\"><\/i>\n<p class=\"text\"><strong>Leucovorin:<\/strong>\u00a0It has been shown to rescue methotrexate and boost 5-FU potency. It must be converted to L-form in the body.<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-arrows-turn-right\"><\/i>\n<p class=\"text\"><strong>Levoleucovorin:<\/strong>\u00a0This pure L-isomer is the active form of leucovorin. It is stronger, more bioavailable, and needs fewer doses than racemic leucovorin.<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-arrows-turn-right\"><\/i>\n<p class=\"text\"><strong>Folic acid:<\/strong>\u00a0Methotrexate inhibits dihydrofolate reductase (DHFR), hence folic acid is ineffective in methotrexate toxicity.<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-arrows-turn-right\"><\/i>\n<p class=\"text\"><strong>Calcium Folinate:<\/strong>\u00a0A leucovorin salt utilized in therapeutic injectable formulations.<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-arrows-turn-right\"><\/i>\n<p class=\"text\"><strong>Glucarpidase:<\/strong>\u00a0It is a carboxypeptidase enzyme. It quickly breaks down methotrexate in cases of acute toxicity or kidney problems.<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<h2 class=\"wp-block-heading\"><strong>Precautions &amp; Warnings<\/strong><\/h2>\n<p>In methotrexate rescue treatments, it should not be confused with folic acid.<\/p>\n<p>Reversing methotrexate-induced nephrotoxicity is not possible with leucovorin.<\/p>\n<p>People who are prone to seizures should be cautious when taking anti-epileptic medications.<\/p>\n<p>Avoid intrathecal administration if possible.<\/p>\n<p>Patients with folate analogue allergies may experience cross-reactivity.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Compatibility with Other Medicines<\/strong><\/h2>\n<div id=\"ilbIconList-1d815635-4\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-atom\"><\/i>\n<p class=\"text\"><strong>Compatible<\/strong><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"ilbIconList-882b1ab3-1\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-arrow-right-from-bracket\"><\/i>\n<p class=\"text\">Methotrexate (IV use)<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-arrow-right-from-bracket\"><\/i>\n<p class=\"text\">5-Fluorouracil (as an adjunct)<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-arrow-right-from-bracket\"><\/i>\n<p class=\"text\"><a href=\"https:\/\/www.actizapharma.com\/product\/trimethoprim-tablets\/\" data-type=\"link\" data-id=\"https:\/\/www.actizapharma.com\/product\/trimethoprim-tablets\/\">Trimethoprim<\/a>\u00a0(toxicity reversal)<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"ilbIconList-9f7da4e8-0\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-atom\"><\/i>\n<p class=\"text\"><strong>Avoid\/Monitor<\/strong><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"ilbIconList-582bb4de-5\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-arrow-right-from-bracket\"><\/i>\n<p class=\"text\">Phenytoin, Phenobarbital, Primidone<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-arrow-right-from-bracket\"><\/i>\n<p class=\"text\">Capecitabine<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-arrow-right-from-bracket\"><\/i>\n<p class=\"text\">Sulfonamides<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<h2 class=\"wp-block-heading\"><strong>Storage<\/strong><\/h2>\n<p>Keep in the fridge at 2\u00b0C to 8\u00b0C (36\u00b0F to 46\u00b0F).<\/p>\n<p>Keep out of the light.<\/p>\n<p>Don\u2019t freeze<\/p>\n<p>Use reconstituted solutions within the time limit that is indicated (usually 12 to 24 hours, depending on how stable they are).<\/p>\n<p>Safely throw away solutions that you don\u2019t need.<\/p>\n","protected":false},"excerpt":{"rendered":"<table class=\"shop_attributes table mt-2 align-middle\">\n<tbody>\n<tr>\n<th class=\"table-light\">Product\/Composition:-<\/th>\n<td class=\"p-2\"><em>Leucovorin Injection<\/em><\/td>\n<\/tr>\n<tr>\n<th class=\"table-light\">Strength:-<\/th>\n<td class=\"p-2\"><em>50mg<\/em><\/td>\n<\/tr>\n<tr>\n<th class=\"table-light\">Form:-<\/th>\n<td class=\"p-2\"><em>Injection<\/em><\/td>\n<\/tr>\n<tr>\n<th class=\"table-light\">Production Capacity:-<\/th>\n<td class=\"p-2\"><em>1 Million Injection\/Month<\/em><\/td>\n<\/tr>\n<tr>\n<th class=\"table-light\">Therapeutic use:-<\/th>\n<td class=\"p-2\"><em>Anti Cancer<\/em><\/td>\n<\/tr>\n<tr>\n<th class=\"table-light\">Package Insert\/Leaflet:-<\/th>\n<td class=\"p-2\"><em>Available upon request<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"featured_media":8711,"comment_status":"open","ping_status":"closed","template":"","meta":{"inline_featured_image":false},"product_brand":[],"product_cat":[15,91,113],"product_tag":[157],"class_list":{"0":"post-8710","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-all-medicine","7":"product_cat-anti-cancer-drugs","8":"product_cat-injection-anti-cancer-drugs","9":"product_tag-injection","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/healaxispharma.com\/index.php?rest_route=\/wp\/v2\/product\/8710","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healaxispharma.com\/index.php?rest_route=\/wp\/v2\/product"}],"about":[{"href":"https:\/\/healaxispharma.com\/index.php?rest_route=\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/healaxispharma.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8710"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/healaxispharma.com\/index.php?rest_route=\/wp\/v2\/media\/8711"}],"wp:attachment":[{"href":"https:\/\/healaxispharma.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8710"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/healaxispharma.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_brand&post=8710"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/healaxispharma.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_cat&post=8710"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/healaxispharma.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_tag&post=8710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}