{"id":8726,"date":"2026-04-09T05:53:31","date_gmt":"2026-04-09T05:53:31","guid":{"rendered":"https:\/\/healaxispharma.com\/?post_type=product&#038;p=8726"},"modified":"2026-04-23T10:53:13","modified_gmt":"2026-04-23T10:53:13","slug":"mitomycin-injection","status":"publish","type":"product","link":"https:\/\/healaxispharma.com\/?product=mitomycin-injection","title":{"rendered":"Mitomycin Injection"},"content":{"rendered":"<h2 class=\"wp-block-heading\"><strong>What is Mitomycin Injection?<\/strong><\/h2>\n<p>Mitomycin Injection has Mitomycin C in it, which is a strong antibiotic that fights cancer and comes from the bacteria Streptomyces caespitosus.<\/p>\n<p>It is an alkylating agent that has special bioreductive activation capabilities.<\/p>\n<p>Mitomycin destroys cells by binding DNA strands together.<\/p>\n<p>This prevents DNA synthesis and cell division, which leads to death.<\/p>\n<p>It is used both systemically for different solid tumors and locally (intravesically) for bladder cancer.<\/p>\n<p>The medicine is in the form of a lyophilized powder.<\/p>\n<p>You can mix it up again for an IV injection or an intravesical instillation.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Product Overview<\/strong><\/h2>\n<p>Mitomycin C is the generic name of this solution.<\/p>\n<p>The type of drug is an alkylating antineoplastic antibiotic.<\/p>\n<p>C\u2081\u2085H\u2081\u2088N\u2084O\u2085 is the molecular formula.<\/p>\n<p>334.33 grams per mole is the molecular weight.<\/p>\n<p>Lyophilized powder form for injection.<\/p>\n<p>The route of administration is intravenous infusion and intravesical instillation.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Indications \/ Uses<\/strong><\/h2>\n<p>Mitomycin is used for:<\/p>\n<div id=\"ilbIconList-eece0284-d\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-arrows-turn-right\"><\/i>\n<p class=\"text\">Advanced or metastatic gastric carcinoma<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-arrows-turn-right\"><\/i>\n<p class=\"text\">Pancreatic Cancer<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-arrows-turn-right\"><\/i>\n<p class=\"text\">Breast cancer<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-arrows-turn-right\"><\/i>\n<p class=\"text\">Squamous cell carcinoma of the head and neck<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-arrows-turn-right\"><\/i>\n<p class=\"text\">Lung cancer<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<h2 class=\"wp-block-heading\"><strong>Benefits<\/strong><\/h2>\n<div id=\"ilbIconList-ff61173c-6\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-arrow-right\"><\/i>\n<p class=\"text\"><strong>Dual versatility:<\/strong>\u00a0Works well as both systemic chemotherapy and topical intravesical treatment.<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-arrow-right\"><\/i>\n<p class=\"text\"><strong>Treatment of tumors:<\/strong>\u00a0Demonstrated effectiveness across various tumor types, especially bladder and gastrointestinal malignancies.<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-arrow-right\"><\/i>\n<p class=\"text\"><strong>Localized delivery advantage:<\/strong>\u00a0Intravesical administration lowers systemic toxicity and sends a high concentration of the medicine just where it\u2019s needed.<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-arrow-right\"><\/i>\n<p class=\"text\"><strong>Long-standing clinical use:<\/strong>\u00a0More than 50 years of clinical experience with a well-documented safety record when used correctly.<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<h2 class=\"wp-block-heading\"><strong>Side Effects<\/strong><\/h2>\n<div id=\"ilbIconList-f2b88551-4\" class=\"wp-block-ilb-icon-list  align\">\n<div class=\"ilbIconList left\">\n<ul class=\"lists\">\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Myelosuppression<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Low platelet count, low RBC, and low WBC count<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Delayed marrow suppression (3\u20138 weeks post-treatment)<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Nausea<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Diarrhea<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Lack of hunger<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Hemolytic uremic syndrome<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Interstitial pneumonitis and pulmonary fibrosis<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Rashes<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Mucositis\/stomatitis<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Renal toxicity\/proteinuria (beyond HUS)<\/p>\n<\/li>\n<li class=\"list\"><i class=\"icon fa-solid fa-circle-dot\"><\/i>\n<p class=\"text\">Vesicant extravasation injury<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<h2 class=\"wp-block-heading\"><strong>Mechanism of Action<\/strong><\/h2>\n<p>Mitomycin C is a bioreductive alkylating chemical that, when activated by enzymes inside cells (especially when there isn\u2019t enough oxygen), makes reactive intermediates that connect DNA strands together.<\/p>\n<p>This stops DNA from copying itself and making RNA, which stops cells from dividing and eventually causes them to die.<\/p>\n<p>Its activity is not limited to a certain stage of the cell cycle, however it is most efficient against cancer cells that are proliferating or resting in the late G1 and early S phases.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Dosage &amp; Administration<\/strong><\/h2>\n<h3 class=\"wp-block-heading\"><strong>IV Use (Adults):<\/strong><\/h3>\n<p>IV every 6\u20138 weeks at a dose of 10\u201320 mg\/m\u00b2<\/p>\n<p>IV every 3\u20134 weeks, 8\u201312 mg\/m\u00b2<\/p>\n<p>The maximum cumulative dosage is 60 mg\/m\u00b2. This lowers the risk of hemolytic uremic syndrome and delayed myelosuppression.<\/p>\n<p>Method of administration: a slow IV bolus over 3 to 5 minutes or an infusion of 20 to 50 mL of sodium chloride 0.9%.<\/p>\n<h3 class=\"wp-block-heading\"><strong>Intravesical Use:<\/strong><\/h3>\n<p>20 to 40 mg of Mitomycin in 20 to 40 mL of sterile water or saline is the dose range.<\/p>\n<p>Frequency: Weekly instillations for 8 to 12 weeks, followed by maintenance regimens based on the urologist\u2019s protocol.<\/p>\n<p>Instructions: The patient should not drink anything for 4 to 6 hours before the procedure, and the solution should stay in the bladder for 1 to 2 hours.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Contraindications<\/strong><\/h2>\n<p>Hypersensitivity to Mitomycin or its ingredients<\/p>\n<p>Infections that are not under control<\/p>\n<p>For use inside the bladder, rupture of the bladder wall, or active gross hematuria<\/p>\n<h2 class=\"wp-block-heading\"><strong>Precautions &amp; Warnings<\/strong><\/h2>\n<p>Only take it if prescribed from people who are experts in oncology or urology.<\/p>\n<p>Keep an eye on CBC, liver enzymes, and kidney function on a regular basis.<\/p>\n<p>Patients with previous chest irradiation or concurrent\u00a0<a href=\"https:\/\/www.actizapharma.com\/product\/bleomycin\/\" data-type=\"link\" data-id=\"https:\/\/www.actizapharma.com\/product\/bleomycin\/\">bleomycin<\/a>\u00a0therapy have a higher risk of pulmonary damage.<\/p>\n<p>Pregnancy Category D \u2013 teratogenic; contraception necessary during and after to treatment.<\/p>\n<p>Do not breastfeed while on therapy or for a time following the last dosage.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Drug Interactions<\/strong><\/h2>\n<p>Additive toxicity with other myelosuppressive drugs.<\/p>\n<p>Vinca alkaloids with bleomycin raise the risk of lung problems.<\/p>\n<p>During treatment, live vaccinations should not be used.<\/p>\n<p>Drugs that are nephrotoxic may make kidney problems worse.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Storage &amp; Handling<\/strong><\/h2>\n<p>Keep unopened vials at room temperature (below 25\u00b0C) and out of the light.<\/p>\n<p>You should use reconstituted solutions right away. If you need to store them, follow the manufacturer\u2019s stability instructions.<\/p>\n<p>When handling cytotoxic substances, wear gloves, masks, and protective clothes, and do so in a biological safety cabinet.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Clinical Considerations<\/strong><\/h2>\n<p>In patients with renal or hepatic impairment, dose modification is necessary.<\/p>\n<p>Elder people may be more sensitive to the harmful effects of drugs.<\/p>\n<p>Check carefully for delayed myelosuppression for up to eight weeks after the treatment.<\/p>\n<p>To lower systemic absorption, avoid catheterization stress while using\u00a0<a href=\"https:\/\/www.cancer.org\/cancer\/types\/bladder-cancer\/treating\/intravesical-therapy.html#:~:text=With%20intravesical%20therapy%2C%20the%20doctor,%5Bshow%5D\" target=\"_blank\" rel=\"noopener noreferrer nofollow\" data-type=\"link\" data-id=\"https:\/\/www.cancer.org\/cancer\/types\/bladder-cancer\/treating\/intravesical-therapy.html#:~:text=With%20intravesical%20therapy%2C%20the%20doctor,%5Bshow%5D\">intravesical<\/a>.<\/p>\n<h2 class=\"wp-block-heading\"><strong>Comparison With Other Anticancer Agents<\/strong><\/h2>\n<p>Mitomycin C is not like most cancer medications.<\/p>\n<p>It functions as an antibiotic that is activated by bioreduction and alkylates cells.<\/p>\n<p>It works even in tumors with low oxygen levels and doesn\u2019t have to be given at a certain time in the cell cycle.<\/p>\n<p>Compared to platinums, it is less harmful to the kidneys and ears.<\/p>\n<p>But it has a larger chance of causing delayed myelosuppression and hemolytic uremic syndrome.<\/p>\n<p>It doesn\u2019t cause heart problems like anthracyclines do, but it does have the potential of lung problems and vesicant toxicity.<\/p>\n<p>It suppresses the marrow more than antimetabolites do. But it doesn\u2019t cause hand-foot syndrome.<\/p>\n<p>Also, it doesn\u2019t cause as many GI adverse effects as topoisomerase inhibitors.<\/p>\n<p>Its specific strength is in chemoradiation regimens, like for anal cancer, and intravesical bladder therapy.<\/p>\n<p>Not many systemic medications function effectively in these locations.<\/p>\n<h2 class=\"wp-block-heading\"><strong>FAQs<\/strong><\/h2>\n<h3 class=\"wp-block-heading\"><strong>Can Mitomycin be used alone?<\/strong><\/h3>\n<p>Yes. It can be used alone to treat bladder cancer (intravesical) and several other types of cancer that affect the whole body. But combined regimens usually work better.<\/p>\n<h3 class=\"wp-block-heading\"><strong>How long does the treatment last?<\/strong><\/h3>\n<p>It depends on the indication:<\/p>\n<p>IV: Every 3\u20138 weeks, until disease progression or unacceptable toxicity or the side effects are too bad.<\/p>\n<p>Intravesical: Usually 8 to 12 weekly instillations, with maintenance cycles sometimes following.<\/p>\n<h3 class=\"wp-block-heading\"><strong>Is hair loss permanent?<\/strong><\/h3>\n<p>No. Alopecia is usually just transient and goes away after therapy stops.<\/p>\n","protected":false},"excerpt":{"rendered":"<table class=\"shop_attributes table mt-2 align-middle\">\n<tbody>\n<tr>\n<th class=\"table-light\">Product\/Composition:-<\/th>\n<td class=\"p-2\"><em>Mitomycin Injection<\/em><\/td>\n<\/tr>\n<tr>\n<th class=\"table-light\">Strength:-<\/th>\n<td class=\"p-2\"><em>2mg, 10mg<\/em><\/td>\n<\/tr>\n<tr>\n<th class=\"table-light\">Form:-<\/th>\n<td class=\"p-2\"><em>Injection<\/em><\/td>\n<\/tr>\n<tr>\n<th class=\"table-light\">Production Capacity:-<\/th>\n<td class=\"p-2\"><em>1 Million Injection\/Month<\/em><\/td>\n<\/tr>\n<tr>\n<th class=\"table-light\">Therapeutic use:-<\/th>\n<td class=\"p-2\"><em>Anti Cancer<\/em><\/td>\n<\/tr>\n<tr>\n<th class=\"table-light\">Package Insert\/Leaflet:-<\/th>\n<td class=\"p-2\"><em>Available upon request<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"featured_media":8727,"comment_status":"open","ping_status":"closed","template":"","meta":{"inline_featured_image":false},"product_brand":[],"product_cat":[15,91,113],"product_tag":[157],"class_list":{"0":"post-8726","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-all-medicine","7":"product_cat-anti-cancer-drugs","8":"product_cat-injection-anti-cancer-drugs","9":"product_tag-injection","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/healaxispharma.com\/index.php?rest_route=\/wp\/v2\/product\/8726","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healaxispharma.com\/index.php?rest_route=\/wp\/v2\/product"}],"about":[{"href":"https:\/\/healaxispharma.com\/index.php?rest_route=\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/healaxispharma.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8726"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/healaxispharma.com\/index.php?rest_route=\/wp\/v2\/media\/8727"}],"wp:attachment":[{"href":"https:\/\/healaxispharma.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8726"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/healaxispharma.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_brand&post=8726"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/healaxispharma.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_cat&post=8726"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/healaxispharma.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_tag&post=8726"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}